| guanine nucleotide-binding protein (G protein), alpha inhibiting activity polypeptide 1 | |
|---|---|
| Identifiers | |
| Symbol | GNAI1 |
| Entrez | 2770 |
| HUGO | 4384 |
| OMIM | 139310 |
| RefSeq | NM_002069 |
| UniProt | P63096 |
| Other data | |
| Locus | Chr. 7 q21-q22 |
| guanine nucleotide-binding protein (G protein), alpha inhibiting activity polypeptide 2 | |
|---|---|
| Identifiers | |
| Symbol | GNAI2 |
| Alt. symbols | GNAI2B |
| Entrez | 2771 |
| HUGO | 4385 |
| OMIM | 139360 |
| RefSeq | NM_002070 |
| UniProt | P04899 |
| Other data | |
| Locus | Chr. 3 p21 |
| guanine nucleotide-binding protein (G protein), alpha inhibiting activity polypeptide 3 | |
|---|---|
| Identifiers | |
| Symbol | GNAI3 |
| Entrez | 2773 |
| HUGO | 4387 |
| OMIM | 139370 |
| RefSeq | NM_006496 |
| UniProt | P08754 |
| Other data | |
| Locus | Chr. 1 p13 |
Gi alpha subunit (or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit that inhibits the production of cAMP from ATP.[1]
Contents |
The following G protein-coupled receptors couple to the Gi subunit:
See also: function of cAMP-dependent protein kinase
Gi mainly inhibits the cAMP dependent pathway by inhibiting adenylate cyclase activity, decreasing the production of cAMP from ATP, which, in turn, results in decreased activity of cAMP-dependent protein kinase. Therefore, the ultimate effect of Gi is the opposite of cAMP-dependent protein kinase.
It is also attributed a minor role in activation of the phospholipase C pathway.[2] Growth hormone is required for normal postnatal growth, bone growth, regulatory effects on protein, carbohydrate, and lipid metabolism.[3] although this is mainly a function of the Gq alpha subunit.
There are several types of Gi: Gia1, Gia2, Gia3 and Gia4
Gia1 or Gi1 is encoded by the gene GNAI1.
Gia2 or Gi2 is encoded by the gene GNAI2.
Gia3 or Gi3 is encoded by the gene GNAI3.
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